• 钙调素 来源于牛睾丸

  • 产品编号:64012
    CAS号:77107-46-1
  • 别名:CaM 磷酸二酯酶 3′:5′-环核苷酸活化剂
  • 订货编号
  • 规格
  • 包装
  • 单价
  • 优惠价
  • COA
  • 数量
  • A64012-1mg
  • ≥98%
  • 1mg
  • 1934.00
  • A64012-2.5mg
  • ≥98%
  • 2.5mg
  • 3895.00

化学性质

属性

存贮条件 储存温度-20°C

描述

产品介绍 Calmodulin is a bioactive protein isolated from bovine testes with a molecular weight of 16,7 kDa. The material is derived from cattle born and raised in Sweden, a country where BSE is non-existing. Calmodulin is a calcium-binding protein expressed in many eukaryotic cells. By binding to and regulating various protein targets, it affects cellular processes such as metabolism, nerve growth, apoptosis, inflammation, muscle contraction and memory. Many proteins use Calmodulin as a calcium sensor and signal transducer, as the proteins themselves are not able to bind calcium. The molecule can bind a maximum of four calcium ions and by undergoing post-translational modifications such as acetylation, phosphorylation, proteolytic cleavage and methylation, its functions can potentially be altered. Calmodulin is supplied as a lyophilized white powder or flocculate from 50 mM NH4HCO3 with 10 μM CaCl2. No preservatives are added. The protein content is analyzed by amino acid assay and is never less than 80 % of weighed substance. The material has been subjected to an acid treatment for minimum 30 min. The protein is derived from a single batch and is homogenous.
别名 CaM 磷酸二酯酶 3′:5′-环核苷酸活化剂;CaM, Phosphodiesterase 3′:5′-cyclic nucleotide activator
生化机理 环核苷酸依赖性磷酸二酯酶活化所需的 Ca2 结合蛋白。它也是一氧化氮合成酶、钙调磷酸酶以及多种激酶的辅因子/活化剂,这些激酶包括 ATP 酶、肌球蛋白轻链激酶和 CAM 激酶 I、II、III。它通过环二磷酸腺苷核糖介导利阿诺定受体活化并且与细胞内 Ca2 的内稳态有关。
应用 Protein calcium binding studies on the regulation of a multitude of different protein targets; Activation of cyclic nucleotide-dependent phosphodiesterase; Co-factor/activator for kinase studies; Studies of edema factor toxin and anthrax bacteria

危险性质

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